Basis of differentiation | CD4 cells | CD8 cells |
Definition | Are white blood cells that play a key role in fighting against infection | Are cytotoxic cells that play a key role in inducing apoptosis of cancerous or infectious cells |
Also known as | T helper cells | Cytotoxic T cells |
Antigen recognition | Only recognize antigens presented by Major Histocompatibility Complex (MHC) Class II | Only recognize antigens presented by MHC Class I |
Mechanism of action | Trigger the immune response by recognizing pathogens and secreting cytokines that signal other immune cells | Destroy infected and cancerous cells by phagocytosis |
Function | Play a key role in antigen presentation to B cells | Play a key role in indirect phagocytosis |