What are the differences between capillary electrophoresis and high-performance liquid chromatography (HPLC)?

Question

Accepted Answer

Basis of differentiation

Capillary electrophoresis

HPLC

Definition

Is a method for sorting charged particles by their movement in an electric field through the use of an applied voltage

Is a technique used to separate, identify, and quantify components in a mixture using chromatography

Principle

Separation based on electrophoretic mobility of ions/molecules

Separates components of a mixture by their differing  interactions with the stationary phase and the mobile phase

Flow type

Flat flow (gives narrower peaks and higher resolution)

Pumped parabolic flow

Capillary type

Exclusive to thin capillaries

Has a wide range of column lengths and packing

Complexity

Is comparatively simpler

Is comparatively more complex

Stationary phase

None (separation occurs in buffer-filled capillary)

Solid stationary phase packed in a column

Basis of differentiation	Capillary electrophoresis	HPLC
Definition	Is a method for sorting charged particles by their movement in an electric field through the use of an applied voltage	Is a technique used to separate, identify, and quantify components in a mixture using chromatography
Principle	Separation based on electrophoretic mobility of ions/molecules	Separates components of a mixture by their differing interactions with the stationary phase and the mobile phase
Flow type	Flat flow (gives narrower peaks and higher resolution)	Pumped parabolic flow
Capillary type	Exclusive to thin capillaries	Has a wide range of column lengths and packing
Complexity	Is comparatively simpler	Is comparatively more complex
Stationary phase	None (separation occurs in buffer-filled capillary)	Solid stationary phase packed in a column