Basis of differentiation | Capillary electrophoresis | HPLC |
Definition | Is a method for sorting charged particles by their movement in an electric field through the use of an applied voltage | Is a technique used to separate, identify, and quantify components in a mixture using chromatography |
Principle | Separation based on electrophoretic mobility of ions/molecules | Separates components of a mixture by their differing interactions with the stationary phase and the mobile phase |
Flow type | Flat flow (gives narrower peaks and higher resolution) | Pumped parabolic flow |
Capillary type | Exclusive to thin capillaries | Has a wide range of column lengths and packing |
Complexity | Is comparatively simpler | Is comparatively more complex |
Stationary phase | None (separation occurs in buffer-filled capillary) | Solid stationary phase packed in a column |