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AAT Bioquest

What are the differences between cleavage and mitosis?

Posted November 30, 2023


Answer

Basis of differentiation

Cleavage

Mitosis

Definition

Cleavage is the initial division of the parent cytoplasm into cytoplasms of 2 daughter cells

Mitosis is a type of cell division which results in 2 genetically identical daughter cells from the parent nucleus

Occurrence

Occurs only in animal cells (in the zygote)

Occurs in animal and plant cells

Growth

Growth does not occur

Growth occurs during interphase

Oxygen consumption

Oxygen consumption is high 

Oxygen consumption is low

Result 

Cleavage ends with the formation of a blastocyst

Mitosis results in 2 genetically identical daughter cells

Size of end products

Size of blastomeres decreases as their number increases

Size of the daughter cells remain constant 

DNA synthesis

DNA synthesis occurs at a much higher rate to produce chromosomes for blastomeres

DNA synthesis occurs at normal speeds

Interphase

Interphase is short (due to the modified cell cycle without G1 and G2 phases) and blastomeres do not grow during this phase 

Interphase is long and daughter cells grow during this phase

Additional resources

Cleavage

Cell Cycle Assays

Cell Meter™ Fluorimetric Live Cell Cycle Assay Kit *Green Fluorescence Optimized for Flow Cytometry*