Basis of differentiation | Open mitosis | Closed mitosis |
Definition | Open mitosis is the separation of chromosomes subsequent to nuclear envelope breakdown (NEBD) | Closed mitosis is the separation of chromosomes and spindle formation without NEBD |
Occurrence | In multicellular organisms | Occurs in lower eukaryotes (typically in fungi) |
Mechanism | The nuclear envelope disintegrates prior to the chromosomes segregating | Chromosome division occurs within the cell nucleus |
Significance of evolution | Open mitosis has been altered several times during evolution | Is the oldest mechanism of eukaryotic cell division |
Spindle formation | Spindle fibers form within the nucleus | Spindle fibers form outside of the nucleus |
Nuclear membrane | The nuclear membrane disintegrates and then re-forms around 2 sets of segregated chromosomes | The nuclear membrane remains intact |