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What are the differences between open and closed mitosis?
Posted November 30, 2023

Answer

Basis of differentiation

Open mitosis

Closed mitosis

Definition
Open mitosis is the separation of chromosomes subsequent to nuclear envelope breakdown (NEBD)
Closed mitosis is the separation of chromosomes and  spindle formation without NEBD
Occurrence
In multicellular organisms
Occurs in lower eukaryotes (typically in fungi)
Mechanism
The nuclear envelope disintegrates prior to the chromosomes segregating  
Chromosome division occurs within the cell nucleus
Significance of evolution
Open mitosis has been altered several times during evolution
Is the oldest mechanism of eukaryotic cell division
Spindle formation
Spindle fibers form within the nucleus
Spindle fibers form outside of the nucleus 
Nuclear membrane
The nuclear membrane disintegrates and then re-forms around 2 sets of segregated chromosomes
The nuclear membrane remains intact