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AAT Bioquest

What are the differences between nucleotide and nucleoside?

Posted February 23, 2024


Answer

Basis of differentiation 

Nucleotide

Nucleoside

Definition 

Is a monomer of nucleic acids such as DNA and RNA

Is a nucleobase linked to a pentose sugar molecule

Composition 

Composed of a pentose sugar, a nitrogenous base and phosphate groups

Composed of a nitrogenous base and a pentose sugar

Presence of phosphate group

Phosphate group is present and is an essential part of its structure

Phosphate group is absent

Functions 

  • Is a precursor of DNA, RNA and polynucleotide
  • Act as energy-storing molecules

Serves as a precursor of nucleotide 

Examples 

  • Guanosine diphosphate
  • Uridine triphosphate
  • Adenosine diphosphate
  • Cytidine monophosphate
  • Guanosine
  • Uridine
  • Adenosine
  • Cytidine 
Additional resources

Comparison of the amino acid and nucleotide sequences between human and two guinea pig major basic proteins

DNA and RNA Quantitation

Helixyte™ Green Fluorimetric dsDNA Quantitation Kit *Optimized for Broad Dynamic Range*