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What are the differences between Robertsonian and reciprocal translocation?
Posted February 3, 2024
Cellular ProcessesDNA and RNA QuantitationNucleic AcidsNucleusPhysiological Probes
Answer
Robertsonian Translocation 
  • Is a type of chromosomal abnormality caused by the exchange of genetic material between acrocentric chromosome pairs
  • Results in the formation of a single, larger chromosome and the loss of two smaller satellite chromosomes
  • Does not have major phenotypic consequences in carriers as there is no net gain or loss of genetic material although there is a risk of unbalanced chromosomal rearrangements in offspring
Reciprocal translocation
  • Is a type of chromosomal abnormality caused by the balanced exchange of chromosome fragments between non-homologous chromosome pairs
  • Results in the exchange of segments of genetic material between the two chromosomes
  • The consequences can be varied depending on the breakpoints involved and whether there is a net gain or loss of genetic material
Additional resources
Robertsonian and Balanced Reciprocal Translocation in Both Child and Mother with a History of Recurrent Abortions DNA and RNA Quantitation Helixyte™ Green Fluorimetric dsDNA Quantitation Kit *Optimized for Broad Dynamic Range*

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