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What are the differences between Robertsonian and reciprocal translocation?
Posted February 3, 2024

Answer

Robertsonian Translocation 

  • Is a type of chromosomal abnormality caused by the exchange of genetic material between acrocentric chromosome pairs
  • Results in the formation of a single, larger chromosome and the loss of two smaller satellite chromosomes
  • Does not have major phenotypic consequences in carriers as there is no net gain or loss of genetic material although there is a risk of unbalanced chromosomal rearrangements in offspring

Reciprocal translocation

  • Is a type of chromosomal abnormality caused by the balanced exchange of chromosome fragments between non-homologous chromosome pairs
  • Results in the exchange of segments of genetic material between the two chromosomes
  • The consequences can be varied depending on the breakpoints involved and whether there is a net gain or loss of genetic material