AAT Bioquest

What are the general features of inclusion bodies?

Posted November 16, 2022


Inclusion bodies are tiny particles with abnormal structures that are freely suspended and floating within the cytoplasmic matrix, usually in endothelial, epithelial, and nerve cells. 

Inclusion bodies are generally acidophilic and may be crystalline aggregates of virions. They have a characteristic staining property and appear as pink structures when stained with methylene blue dye or gypsum. These structures represent degenerative modifications produced by a viral infection. They are composed of virus antigens present at the site of virus synthesis. Inclusion bodies function as reserve deposits, storing nutrients to be used in case of a deficiency. 

Additional resources

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