What are the limitations of RNA interference (RNAi)? | AAT Bioquest

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What are the limitations of RNA interference (RNAi)?

Posted August 15, 2024

DNA and RNA Quantitation Gene Expression Analysis & Genotyping Nucleic Acids Nucleus

Answer

One limitation is the off-target effects. RNAi can sometimes affect unintended genes, leading to potential side effects. Another limitation is possible delivery issues. Introducing siRNA into cells effectively remains a challenge, although advancements in delivery reagents are improving this process.

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RNA Interference–Based Therapy and Its Delivery Systems Gene Expression Analysis & Genotyping Portelite™ Fluorimetric RNA Quantitation Kit*Optimized for Cytocite™ and Qubit™ Fluorometers*

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