What are the targets of the commonly used protease inhibitors?

Protease inhibitor

Targets

AEBSF

Serine proteases: Plasmin, thrombin, trypsin, chymotrypsin and kallikrein. 

EDTA

Metalloproteases

Bestatin

Amino-peptidases: leucine aminopeptidase,triamino peptidase and aminopeptidase B

Aprotinin

Serine proteases: chymotrypsin, plasmin, trypsinogen, kallikrein and urokinase

E64

Cysteine proteases: calpain, cathepsin B and papain

Leupeptin

Serine and cysteine proteases: papain, trypsin, calpain and cathepsin D

PMSF

Serine proteases: trypsin, chymotrypsin, thrombin and papain

Pepstatin A

Aspartic acid proteases: pepsinde, chymosin, protease B, rennin, and cathepsin D