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What are the targets of the commonly used protease inhibitors?
Posted March 21, 2024
Antibodies and ProteomicsAntibody and Protein LabelingEnzymesProteases
Answer
Protease inhibitor
Targets
AEBSF
Serine proteases: Plasmin, thrombin, trypsin, chymotrypsin and kallikrein. 
EDTA
Metalloproteases
Bestatin
Amino-peptidases: leucine aminopeptidase,triamino peptidase and aminopeptidase B
Aprotinin
Serine proteases: chymotrypsin, plasmin, trypsinogen, kallikrein and urokinase
E64
Cysteine proteases: calpain, cathepsin B and papain
Leupeptin
Serine and cysteine proteases: papain, trypsin, calpain and cathepsin D
PMSF
Serine proteases: trypsin, chymotrypsin, thrombin and papain
Pepstatin A
Aspartic acid proteases: pepsinde, chymosin, protease B, rennin, and cathepsin D
Additional resources
Screening, Purification and Characterization of Protease Inhibitor from Capsicum frutescensProteasesAmplite® Universal Fluorimetric Protease Activity Assay Kit *Green Fluorescence*

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