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AAT Bioquest

What are the differences between proteases and proteinases?

Posted March 21, 2024


Answer

Basis of differentiation

Proteases

Proteinases

Definition

Is an enzyme which catalyzes the breakdown of proteins into smaller polypeptides or single amino acids

Are enzymes which hydrolyze peptide bonds in proteins

Type

Can be endopeptidases or exopeptidases

Are endopeptidases

Substrate specificity

Proteases typically exhibit broader substrate specificity, targeting a wide range of peptide bonds in proteins.

Proteinases exhibit more specific substrate preferences, cleaving peptide bonds at specific amino acid residues or within particular protein domains

Additional resources

Proteinase

Proteases

Amplite® Universal Fluorimetric Protease Activity Assay Kit *Green Fluorescence*