Regulatory T cells or Tregs are white blood cells that are involved in regulating the body’s immune response and preventing it from over-reacting to harmful invaders known as antigens. There are two types of regulatory T cells – natural Tregs and Induced Tregs. 

Natural Tregs: 

• Develop in the thymus during T cell maturation 
• Target self-antigens and help to control autoimmune inflammation

Induced Tregs: 

• Are derived from naïve CD4+ T cells in the periphery
• Target foreign antigens and neoantigens 
• Get activated on receiving signals from small proteins called cytokines