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AAT Bioquest

What does methylation do to chromatin?

Posted January 3, 2024


Answer

Methylation compresses the structure of chromatin. 

In the methylation process, a methyl group that gets added to the tail of histone proteins maintains the positive charge of the histones. The strong attraction between the positively charged methylated histone and negatively charged DNA causes the DNA to get tightly wound up, compressing the chromatin structure. 

Additional resources

The role of DNA methylation in setting up chromatin structure during development

DNA Methylation

Helixyte™ Green ssDNA reagent