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AAT Bioquest

What is the structural difference between ribose and deoxyribose?

Posted February 20, 2023


Answer

The structure of ribose and deoxyribose are nearly identical, with one key difference. Ribose consists of a hydroxyl group at carbon 2. In contrast, deoxyribose has a hydrogen atom at the same carbon; it lacks an oxygen atom. Because of this, the deoxyribose molecule is more stable than the ribose molecule. The molar mass of ribose is 150.13 g/mol while deoxyribose has a molar mass of 134.14 g/mol. The difference in molar mass is because of the lack of one oxygen atom in the deoxyribose molecule. 

Additional resources

Comparison of the acid-base properties of ribose and 2'-deoxyribose nucleotides

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