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AAT Bioquest

What is the structure of a lipid?

Posted October 12, 2023


Answer

The structure of a lipid typically comprises a glycerol molecule and two hydrophobic fatty acid tails. Some types of lipids also have a hydrophilic phosphate group. 

The glycerol molecule, which functions as the backbone, is composed of three carbon atoms with one hydroxyl group attached to it. H (hydrogen) atoms occupy the remaining positions on the carbon atom. 

The fatty acid tails are composed of long chains of hydrocarbons with a carboxylic (COOH) group at one end. These hydrocarbon chains are hydrophobic and repel water. 

Phospholipids, which are a type of lipid, also have a phosphate group attached to the glycerol backbone. This phosphate group is hydrophilic and attracts water. 

The hydrophobic fatty acid tails and hydrophilic phosphate group result in the formation of an amphipathic phospholipid molecule. 

Structure of Triglycerides

Triglycerides, which are a type of lipids, consist of one glycerol molecule bonded with three fatty acid molecules. The bonds between the molecules, known as Ester bonds, are covalent in nature.

Additional resources

Molecular simplification of lipid A structure: TLR4-modulating cationic and anionic amphiphiles

Cell Meter™ Intracellular Colorimetric Lipid Peroxidation (MDA) Assay Kit