What's the significance of single-cell sequencing?

Individual cells within a tissue or organ play key roles in the physiology and pathology of the entire organism. The significance of single-cell sequencing is that it allows researchers to examine the unique contributions of individual cells within a tissue or organ, providing a detailed understanding of cellular diversity. This unprecedented level of detail is especially valuable for studying rare cells, exploring variations within cell populations, and investigating complex biological processes. It has been used to study rare immune cells, analyze human microbiomes, uncover mechanisms of tumor resistance, discover new gene functions, and predict tumor progression based on cellular heterogeneity. These are just a few of numerous applications that have been made possible by the exceptionality of single cell sequencing technologies.