Name: EDTA Azide
Brand: AAT Bioquest
SKU: 65007
Price: 301 USD
Availability: InStock

EDTA Azide

EDTA azide is an azide-functionalized chelating agent that enables bioorthogonal attachment of EDTA to alkyne-modified targets, useful for creating metal-responsive probes and targeted MRI contrast agents.

Azide Functionality: Reacts with alkynes via CuAAC or strain-promoted click chemistry
Preserved Chelation: Maintains EDTA's high affinity for divalent and trivalent metal ions
MRI Contrast Development: Ideal for creating targeted gadolinium-based imaging agents
Bioorthogonal Labeling: Enables selective conjugation in complex biological environments

Datasheet

SDS

COA

Catalog	Size	Price	Quantity
65007	5 mg	Price

Overview

EDTA azide is an excellent building block to develop site-specific ethylenediaminetetraacetic acid (EDTA) probes for variety of biomedical applications. It readily reacts with an alkyne compound (such as DBCO) under the well-known click chemistry conditions. EDTA is the most commonly used chelator for complexing transitional metal ions. EDTA chelation therapy uses the chelating agent, EDTA, to remove heavy metals and minerals from the body. It involves injecting EDTA into the bloodstream, where it binds to these substances, allowing them to be excreted through urine. EDTA is approved for treating lead poisoning, but it's also used in other conditions, including coronary artery disease and arthritis.

Calculators

Common stock solution preparation

Table 1. Volume of DMF needed to reconstitute specific mass of EDTA Azide to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.

	0.1 mg	0.5 mg	1 mg	5 mg	10 mg
1 mM	130.078 µL	650.39 µL	1.301 mL	6.504 mL	13.008 mL
5 mM	26.016 µL	130.078 µL	260.156 µL	1.301 mL	2.602 mL
10 mM	13.008 µL	65.039 µL	130.078 µL	650.39 µL	1.301 mL

Molarity calculator

Enter any two values (mass, volume, concentration) to calculate the third.

Mass (Calculate)		Molecular weight		Volume (Calculate)		Concentration (Calculate)		Moles
mg	÷	768.77 g/mol	=	mL	x	mM	=	mmol

References

View all 25 references: Citation Explorer

Click Conjugates of Artificial Ribonucleases: Sequence Specific Cleavage with Multiple Turnover.

Authors:

Weber, Sandra and Weinrich, Timo and Scheffer, Ute and Kalden, Elisabeth and Göbel, Michael W

Journal:

Chemistry (Weinheim an der Bergstrasse, Germany) (2025): e202500451

Decoration of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) with N-oxides increases the T1 relaxivity of Gd-complexes.

Authors:

Kerpa, Svenja and Schulze, Verena R and Holzapfel, Malte and Cvancar, Lina and Fischer, Markus and Maison, Wolfgang

Journal:

ChemistryOpen (2024): e202300298

Exploring the Influence of Spacers in EDTA-β-Cyclodextrin Dendrimers: Physicochemical Properties and In Vitro Biological Behavior.

Authors:

González-Méndez, Israel and Sorroza-Martínez, Kendra and González-Sánchez, Ignacio and Gracia-Mora, Jesús and Bernad-Bernad, María Josefa and Cerbón, Marco and Rivera, Ernesto and Yatsimirsky, Anatoly K

Journal:

International journal of molecular sciences (2023)

Synthesis of β-Cyclodextrin-Decorated Dendritic Compounds Based on EDTA Core: A New Class of PAMAM Dendrimer Analogs.

Authors:

González-Méndez, Israel and Loera-Loera, Esteban and Sorroza-Martínez, Kendra and Vonlanthen, Mireille and Cuétara-Guadarrama, Fabián and Bernad-Bernad, María Josefa and Rivera, Ernesto and Gracia-Mora, Jesús

Journal:

Pharmaceutics (2022)

Click chemistry inspired synthesis of andrographolide triazolyl conjugates for effective fluorescent sensing of ferric ions.

Authors:

Pandey, Nishant and Jyoti, and Singh, Mangat and Dwivedi, Pratibha and Sahoo, Subash C and Mishra, Bhuwan B

Journal:

Natural product research (2022): 5438-5448

Physical properties

Molecular weight	768.77
Solvent	DMF

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C); Minimize light exposure

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Page updated on May 8, 2026