Name: iFluor® 405-dextran conjugate (average MW = ~10K)
Brand: AAT Bioquest
SKU: 21713
Price: 199 USD
Availability: InStock

iFluor® 405-dextran conjugate (average MW = ~10K)

iFluor® 405-dextran (10 kDa) is a bright blue-fluorescent dextran conjugate optimized for violet laser excitation that enables studies of vascular permeability, endocytosis, and molecular transport with minimal size exclusion effects.

Fluorophore: Conjugated to iFluor® 405, a bright, photostable dye with spectral properties similar to Pacific Blue®
Spectral Properties: Ex/Em max = 403/427 nm
Dextran Backbone: ~10,000 Da dextran provides efficient intracellular uptake and diffusion, ideal for fluid-phase marker applications
Water Solubility: Supplied as a lyophilized powder; readily soluble in aqueous buffers for experimental convenience
Application Scope: Suitable for investigating endocytic pathways, monitoring vascular permeability, and labeling intracellular compartments in live or fixed cells

Datasheet

SDS

COA

Catalog	Size	Price	Quantity
21713	10 mg	Price

Overview

iFluor® 405–dextran conjugate (average MW = ~10,000 Da) is a water-soluble fluorescent probe consisting of a 10 kDa dextran backbone labeled with the bright, blue-emitting iFluor® 405 fluorophore. With excitation and emission maxima at approximately 403 nm and 427 nm, respectively, this conjugate is well-suited for use with violet laser–based instruments in applications such as flow cytometry, fluorescence microscopy, and in vivo imaging. The dextran carrier facilitates efficient uptake by cells and tissues, making the conjugate ideal for tracking endocytosis, analyzing vascular permeability, and labeling fluid-phase compartments. iFluor® 405 is spectrally similar to Pacific Blue® and offers excellent photostability and low background fluorescence, enabling consistent and reliable signal detection. The conjugate is supplied as a lyophilized powder and is readily soluble in aqueous buffers for immediate experimental use.

References

View all 50 references: Citation Explorer

The intestinal permeability marker FITC-dextran 4kDa should be dosed according to lean body mass in obese mice.

Authors:

Voetmann, Louise M and Rolin, Bidda and Kirk, Rikke K and Pyke, Charles and Hansen, Axel K

Journal:

Nutrition & diabetes (2023): 1

Destruction of polyelectrolyte microcapsules and release of FITC-dextran from them by the influence of sodium dodecyl sulfonate.

Authors:

Dubrovskii, Alexey V and Kim, Aleksandr L and Musin, Egor V and Tikhonenko, Sergey A

Journal:

Scientific reports (2022): 4032

Retro-orbital injection of FITC-dextran combined with isolectin B4 in assessing the retinal neovascularization defect.

Authors:

Li, Jizhu and Wu, Yuqing and Liu, Bingqian and Huang, Ying and Wu, Qingxiu and Li, Haichun and Xiao, Sainan and Lin, Ying and Li, Tao

Journal:

BMC ophthalmology (2021): 208

FITC-Dextran Release from Cell-Embedded Fibrin Hydrogels.

Authors:

Lepsky, Viki Raz and Natan, Sari and Tchaicheeyan, Oren and Kolel, Avraham and Zussman, Merav and Zilberman, Meital and Lesman, Ayelet

Journal:

Biomolecules (2021)

Hyaluronic Acid and Poly-l-Lysine Layers on Calcium Alginate Microspheres to Modulate the Release of Encapsulated FITC-Dextran.

Authors:

Baldwin, Emily T and Wells, Laura A

Journal:

Journal of pharmaceutical sciences (2021): 2472-2478

Physical properties

Solvent	Water
Dye loading	0.8-1.2

Spectral properties

Correction factor (260 nm)	0.48
Correction factor (280 nm)	0.77
Extinction coefficient (cm ^-1 M ^-1)	37000 ¹
Excitation (nm)	403
Emission (nm)	427
Quantum yield	0.91 ¹

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C); Minimize light exposure

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Page updated on May 8, 2026