Rhod-4™ alkyne

Rhod-4™ alkyne is an excellent building block that can be readily used to prepare a calcium-sensitive bioconjugate for monitoring calcium change spatially for a specific target. It can be conjugated to azido-containing biomolecules via the well-known click chemistry. Rhod-4™ is a fluorescent calcium indicator dye commonly used in cell biology and neuroscience research. It belongs to the family of rhodol-based calcium. Rhod-4™ is a high-affinity calcium indicator dye that exhibits changes in fluorescence intensity upon binding to calcium ions. When Rhod-4™ binds to calcium, its fluorescence intensity increases dramatically, allowing researchers to measure and monitor changes in calcium levels. Compared to the traditional Rhod-2, Rhod-4™ is a superior replacement. It is a valuable tool in calcium imaging research, enabling the detection and quantification of intracellular calcium dynamics. It's fluorescence properties and calcium binding specificity make it suitable for studying calcium signaling in various cell types and biological systems.

Protocol

SDS

COA

Catalog	Size	Price	Quantity
21126	100 ug	Price

References

View all 50 references: Citation Explorer

Mitochondria-Endoplasmic Reticulum Contact Sites Dynamics and Calcium Homeostasis Are Differentially Disrupted in PINK1-PD or PRKN-PD Neurons.

Authors:

Grossmann, Dajana and Malburg, Nina and Glaß, Hannes and Weeren, Veronika and Sondermann, Verena and Pfeiffer, Julia F and Petters, Janine and Lukas, Jan and Seibler, Philip and Klein, Christine and Grünewald, Anne and Hermann, Andreas

Journal:

Movement disorders : official journal of the Movement Disorder Society (2023)

Palmitic acid methyl ester induces cardiac hypertrophy through activating the GPR receptor-mediated changes of intracellular calcium concentrations and mitochondrial functions.

Authors:

Lien, Chih-Feng and Chiu, Hung-Wen and Lee, Wen-Sen and Lin, Jian-Hong and Wang, Yi-Shun and Ting, Pei-Ching and Luo, Yu-Po and Chang, Jui-Chih and Yang, Kun-Ta

Journal:

Journal of cellular physiology (2023): 242-256

Cisplatin induces damage of auditory cells: Possible relation with dynamic variation in calcium homeostasis and responding channels.

Authors:

Zhao, Hao and Xu, Yue and Song, Xinlei and Zhang, Qingchen and Wang, Yajie and Yin, Haiyan and Bai, Xiaohui and Li, Jianfeng

Journal:

European journal of pharmacology (2022): 174662

Inhibitory Effects of 6,8-Diprenylorobol on Endometriosis Progression in Humans by Disrupting Calcium Homeostasis and Mitochondrial Function.

Authors:

Song, Jisoo and Song, Gwonhwa and Park, Sunwoo and Lim, Whasun

Journal:

Antioxidants (Basel, Switzerland) (2022)

NiONPs-induced alteration in calcium signaling and mitochondrial function in pulmonary artery endothelial cells involves oxidative stress and TRPV4 channels disruption.

Authors:

Germande, Ophélie and Baudrimont, Magalie and Beaufils, Fabien and Freund-Michel, Véronique and Ducret, Thomas and Quignard, Jean-François and Errera, Marie-Hélène and Lacomme, Sabrina and Gontier, Etienne and Mornet, Stéphane and Bejko, Megi and Muller, Bernard and Marthan, Roger and Guibert, Christelle and Deweirdt, Juliette and Baudrimont, Isabelle

Journal:

Nanotoxicology (2022): 29-51

Physical properties

Molecular weight	852.85
Solvent	DMSO

Spectral properties

Excitation (nm)	523
Emission (nm)	551
Quantum yield	0.1 ¹

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C); Minimize light exposure
UNSPSC	12352200

Documents

Protocol
Safety Data Sheet
Certificate of Analysis

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Page updated on October 29, 2025