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Rhodamine aldehyde [5-TAMRA aldehyde]

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Physical properties
Molecular weight536.03
Spectral properties
Correction Factor (260 nm)0.32
Correction Factor (280 nm)0.178
Extinction coefficient (cm -1 M -1)90000
Excitation (nm)552
Emission (nm)578
Storage, safety and handling
H-phraseH303, H313, H333
Hazard symbolXN
Intended useResearch Use Only (RUO)
R-phraseR20, R21, R22
StorageFreeze (< -15 °C); Minimize light exposure
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Show More (41)


Molecular weight
Correction Factor (260 nm)
Correction Factor (280 nm)
Extinction coefficient (cm -1 M -1)
Excitation (nm)
Emission (nm)
Rhodamine aldehyde is a reactive fluorescent dye that can react with an amine, hydrazine or hydroxylamine. Aldehyde group is reactive toward amines, hydrazide or hydroxylamine groups from pH 5-9. Unlike amine reactive succinimidyl ester group (NHS), aldehyde can react with N-terminal amine groups at acidic pH, a condition sometimes required for certain bioconjugation reactions. Aldehyde reacts with amine group to form an intermediate Schiff bond. Further reduction with hydride will form a stable C-N bond. Reaction between aldehyde and other groups allows site-specific conjugation and labeling of fluorescein dyes to desired position on targeted molecules. Conjugated rhodamine dye can be easily detected by a common fluorescence instrument under TRITC or Cy3 channel.


Common stock solution preparation

Table 1. Volume of DMSO needed to reconstitute specific mass of Rhodamine aldehyde [5-TAMRA aldehyde] to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.

0.1 mg0.5 mg1 mg5 mg10 mg
1 mM186.557 µL932.784 µL1.866 mL9.328 mL18.656 mL
5 mM37.311 µL186.557 µL373.113 µL1.866 mL3.731 mL
10 mM18.656 µL93.278 µL186.557 µL932.784 µL1.866 mL

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Spectral properties

Correction Factor (260 nm)0.32
Correction Factor (280 nm)0.178
Extinction coefficient (cm -1 M -1)90000
Excitation (nm)552
Emission (nm)578

Product Family

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Rhodamine 800 *CAS 137993-41-0*682704--
Rhodamine B *CAS 81-88-9*54656710600010.71, 0.432
Rhodamine 6G *CAS 989-38-8*52554811600010.951
Rhodamine 110 *CAS 13558-31-1*50052280000-
Rhodamine 123 *CAS 62669-70-9*50852885200-
Fluorescein aldehyde [5-FAM aldehyde]49351783000-
Cy3 aldehyde55556915000010.151
Cy5 aldehyde65167025000010.271, 0.42
XFD488 aldehyde *Same Structure to Alexa Fluor™ 488 aldehyde*499520710000.921



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Journal: Chemistry of Materials (2023)


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Aldehyde dehydrogenase-2 activation decreases acetaminophen hepatotoxicity by prevention of mitochondrial depolarization.
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Super-Resolution Fluorescence Imaging of Arabidopsis thaliana Transfer Cell Wall Ingrowths using Pseudo-Schiff Labelling Adapted for the Use of Different Dyes.
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A novel rhodamine-based colorimetric and fluorometric probe for simultaneous detection of multi-metal ions.
Authors: Zhang, Yuqi and Wang, Wang and Li, Ran and Zhang, Ensheng and Li, Zhonghua and Tang, Long and Han, Bo and Hou, Xiufang and Wang, Ji-Jiang
Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy (2020): 118050
A rhodamine-based turn-on nitric oxide sensor in aqueous medium with endogenous cell imaging: an unusual formation of nitrosohydroxylamine.
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Journal: Chembiochem : a European journal of chemical biology (2018): 2545-2549
The Protective Effect of Jatrorrhizine Against Oxidative Stress in Primary Rat Cortical Neurons.
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Journal: Scientific reports (2017): 6014