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Do B cells have b7?

Posted December 11, 2019


Answer

B7 is the collective name for a family of 10 transmembrane receptor proteins embedded in the cell membrane that perform various regulatory functions for the immune system. B7-1 (also known as CD80) and B7-2 (also known as CD86) are the most prominent and thoroughly studied. The majority of this protein family is expressed on B cells. (See Table 1 below) When B7 was first being studied in the later portion of the 20th century, it was believed that there was only one protein that varied widely in behavior. More types of proteins within the B7 family and greater details of their roles in cellular and systemic health are being continually discovered.

 

Table 1. B7 Glycoprotein B Cell Expression
 Protein Type Expression on B Cells
B7-1 Yes
B7-2 Yes
B7-DC No
B7-H1 Yes
B7-H2 Yes
B7-H3 Yes
B7-H4 Debated
B7-H5 No
B7-H6 No
B7-H7 Induced (Not typically present in healthy cells)
B7-S1 Yes

 

References:

  1. Collins, M., Ling, V., & Carreno, B. M. (2005). The B7 family of immune-regulatory ligands. Genome biology6(6), 223. doi:10.1186/gb-2005-6-6-223
  2. Janakiram, M., Chinai, J. M., Fineberg, S., Fiser, A., Montagna, C., Medavarapu, R., … Zang, X. (2015). Expression, Clinical Significance, and Receptor Identification of the Newest B7 Family Member HHLA2 Protein. Clinical cancer research : an official journal of the American Association for Cancer Research21(10), 2359–2366. doi:10.1158/1078-0432.CCR-14-1495
  3. MacGregor, Heather L., & Ohashi, Pamela S. (2017) Molecular Pathways: Evaluating the Potential for B7-H4 as an Immunoregulatory Target. Clin Cancer Res, (23) (12) 2934-2941; DOI: 10.1158/1078-0432.CCR-15-2440
  4. C D Gimmi, G J Freeman, J G Gribben, K Sugita, A S Freedman, C Morimoto, L M Nadler (1991) B-cell surface antigen B7 provides a costimulatory signal that induces T cells to proliferate and secrete interleukin 2. Proceedings of the National Academy of Sciences, 88 (15) 6575-6579; DOI: 10.1073/pnas.88.15.6575
  5. Zhu, Y., Yao, S., Iliopoulou, B. et al. (2013) B7-H5 costimulates human T cells via CD28H. Nat Commun 4, 2043 doi:10.1038/ncomms3043
  6. Matta J1, Baratin M, Chiche L, Forel JM, Cognet C, Thomas G, Farnarier C, Piperoglou C, Papazian L, Chaussabel D, Ugolini S, Vély F, Vivier E.(2013) Induction of B7-H6, a ligand for the natural killer cell-activating receptor NKp30, in inflammatory conditions. Blood, 122(3):394-404 doi: 10.1182/blood-2013-01-481705. Epub 2013 May 17.
Additional resources

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