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AAT Bioquest

Is BrdU (Bromodeoxyuridine) a teratogen?

Posted September 3, 2021


Answer

Yes, BrdU (Bromodeoxyuridine) is a teratogen. Teratogens are agents that can cause birth defects or abnormalities in developing embryos or fetuses on exposure.

Birth dating neurons with BrdU (Bromodeoxyuridine) is widely used by neurobiologists to monitor cell proliferation in the embryonic, postnatal, and adult brain. Because of its teratogenic, cytotoxic, and mutagenic properties, there are strict procedures in place for its administration, decontamination, and disposal.

Additional resources

Genotoxic and embryotoxic effects of 5-bromodeoxyuridine in the chick embryo

BrdU [5-Bromo-2'-deoxyuridine] *CAS 59-14-3*