What conditions are caused by problems with the endoplasmic reticulum?

Prolonged endoplasmic reticulum stress caused by excessive accumulation of unfolded and misfolded proteins in the ER may contribute to the development and progression of a number of diseases in humans. These may include type 2 diabetes, obesity, atherosclerosis, Alzheimer’s disease, cystic fibrosis, neurodegeneration, cancer, spastic paraplegia, and liver disease.