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What is the difference between a serotype and a subtype of a virus?
Posted April 24, 2020
Antibodies and Proteomics Enzyme-Linked Immunosorbent Assay (ELISA)Antibody and Protein LabelingDNA and RNAEnzymesProtein
Answer
While subtype is simply a broad term for any subclassification under a group, a serotype is a grouping of viruses or other microorganisms based on the type of surface antigens present. Serotyping can be done using a variety of assays, including ELISA and RT-PCR.
Additional resources
Veerasami, M., Singanallur, N.B., Thirumeni, N., Rana, S.K., Shanmugham, R., Ponsekaran, S., Muthukrishnan, M., & Villuppanoor, S.A. (2008). Serotyping of foot-and-mouth disease virus by antigen capture-ELISA using monoclonal antibodies and chicken IgY. The new microbiologica, 31(4), 549-554.Alm, E., Lindegren, G., Falk, K.I., & Lagerqvist, N. (2015). One-step real-time RT-PCR assays for serotyping dengue virus in clinical samples. BMC infectious diseases, 15, 493. doi:10.1186/s12879-015-1226-z