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AAT Bioquest

How are peroxisomes formed?

Posted October 2, 2023


Answer

Peroxisomes are formed in the endoplasmic reticulum in a process that involves three key steps: 

  1. Synthesis and Assembly of Peroxisome Membranes - The ER produces lipids (fats) and membrane proteins needed for peroxisomes.
  2. Import of Matrix Proteins - Once these materials are ready, they need to come together to create a peroxisome. Preperoxisomal vesicles, which are special vesicles derived from the endoplasmic reticulum and carrying different membrane proteins, fuse together, facilitating the creation of the peroxisomal translocon. 
  3. Growth and Maintenance - To complete the formation, the newly assembled translocon acts as a gateway allowing soluble proteins from the surrounding cytosol to enter the peroxisome. Newly formed peroxisomes keep growing and multiplying to fulfill their functions effectively. This happens through processes like peroxisomal fission (division) and segregation, ensuring that the cell maintains the right number of peroxisomes.
Additional resources

Peroxisome formation and maintenance are dependent on the endoplasmic reticulum

Cell Meter™ Intracellular Colorimetric Lipid Peroxidation (MDA) Assay Kit