AAT Bioquest

How do cells protect themselves against cellular stress?

Posted November 30, 2022


Cells protect themselves against cellular stress through several different mechanisms. For example, autophagy, activation of cell cycle arrest, apoptosis, and the heat shock response.

  • Autophagy is triggered when there is nutrient starvation and oxidative stress. Its purpose is to recycle cellular components and damaged organelles.
  • The activation of cell cycle arrest is for creating a stopping point in the cell cycle, where duplication and division is stopped to prevent any further damage.
  • The heat shock response helps protect a cell against damage by acting as chaperons in protein folding, ensuring that proteins do not misfold and keep their required shape.  If the previous methods fail to protect the cell, it will initiate apoptosis as the cell has experienced too much damage or is too old.   
Additional resources

Cell Meter™ Autophagy Assay Kit *Green Fluorescence*

Cell Meter™ Fluorimetric Live Cell Cycle Assay Kit *Red Fluorescence Optimized for Flow Cytometry*

Cellular Stress Responses: Cell Survival and Cell Death

Apoptosis and Necrosis