AAT Bioquest

How does 7-AAD bind to DNA?

Posted May 24, 2022


7-AAD binds to DNA in a specific and straightforward manner. It binds to DNA through interconnecting between base pairs in G-C regions. When 7-AAD becomes bound to the G-C regions, a banding pattern forms in polytene chromosomes and chromatin. This is used for chromosome banding studies, for things like clinical research.

Additional resources

7-AAD [7-Aminoactinomycin D] *CAS 7240-37-1*

Dead cell discrimination with 7-amino-actinomycin D in combination with dual color immunofluorescence in single laser flow cytometry

Cell Viability