What are the advantages of base editing?

One advantage is that base editing enables precise modifications of individual nucleotides within the genome without introducing double-strand breaks (DSBs), allowing for targeted changes to specific DNA sequences. Additionally, compared to other gene editing techniques like CRISPR-Cas9, base editing typically results in fewer off-target mutations because it does not require the introduction of DSBs. Base editing can be applied to various organisms, including bacteria, plants, and animals, making it a versatile tool for genetic manipulation across different species.