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AAT Bioquest

What are the advantages of multiplex genome editing tools?

Posted March 21, 2024


Answer

Multiplex genome-editing (MGE) techniques offers several advantages. One key advantage is that it enables the simultaneous editing of multiple genomic loci, saving time and resources compared to sequential editing approaches. This method also offers versatility in targeting both similar and dissimilar DNA sequences, allowing for the modification of multiple genes sharing conserved regions or targeting multiple sites within the same gene. Multiplex genome editing can target multiple sites within the same gene, different paralogs or alleles, or even distinct genes simultaneously.

Additional resources

Multiplex Automated Genome Engineering (MAGE)

Genome Editing & CRISPR

Transfectamine™ 5000 Transfection Reagent