What are the differences between cAMP and cGMP?

Question

Accepted Answer

Basis of differentiation

cAMP

cGMP

Definition

Is a common second messenger involved in signal transduction cascades

A cyclic nucleotide, which acts as a second messenger like cAMP

Nucleotide type

Is an adenosine nucleotide

Is a guanosine nucleotide

Concentration

Has a high concentration in many tissues

Has a lower concentration in many tissues

Synthesis

Is synthesized from ATP through the enzyme adenylate catalase

Is synthesized from GTP through the enzyme guanylate cyclase

Function

Is involved in the regulation of glycogen, sugar, and lipid metabolism in eukaryotic cells

Is involved in the regulation of ion channel conductance, apoptosis, and smooth muscle relaxation

Basis of differentiation	cAMP	cGMP
Definition	Is a common second messenger involved in signal transduction cascades	A cyclic nucleotide, which acts as a second messenger like cAMP
Nucleotide type	Is an adenosine nucleotide	Is a guanosine nucleotide
Concentration	Has a high concentration in many tissues	Has a lower concentration in many tissues
Synthesis	Is synthesized from ATP through the enzyme adenylate catalase	Is synthesized from GTP through the enzyme guanylate cyclase
Function	Is involved in the regulation of glycogen, sugar, and lipid metabolism in eukaryotic cells	Is involved in the regulation of ion channel conductance, apoptosis, and smooth muscle relaxation