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AAT Bioquest

How is cGMP activated?

Posted July 25, 2023


Answer

cGMP is activated by nitric oxide by interacting with the heme group of the enzyme soluble guanylate cyclase (sGC). This interaction between the two allows sGC to convert GTP into cGMP. This process is known as the NO/cGMP signaling pathway. This pathway is involved in several processes such as the regulation of muscle relaxation, neurotransmission, and hormonal secretion. Once cGMP is produced, it may activate protein kinase G, which leads to activation of myosin phosphate. This in turn leads to the release of calcium from intracellular stores in smooth muscle cells. 

Additional resources

cGMP-Dependent Protein Kinases and cGMP Phosphodiesterases in Nitric Oxide and cGMP Action

cGMP-dependent protein kinase 1 beta Inhibitors (IC50, Ki)

Screen Quest™ Fluorimetric ELISA cAMP Assay Kit