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AAT Bioquest

What are the differences between LD50 and ED50?

Posted March 26, 2024


Answer

Key differences between LD50 and ED50:

LD50:

  • LD50 stands for Lethal Dose 50%. 
  • It indicates the median lethal dose of a substance or the lethal dose for 50% of the individuals tested and is a key measure of drug toxicity. 

ED50:

  • ED50 stands for Effective Dose 50%. 
  • It indicates the median effective dose of a substance or the dose required to achieve 50% of the desired response in 50% of the population. In this case, efficacy is defined as the maximum effect that a drug can cause at any given dose. The smaller the ED50, the more potent the drug.
Additional resources

Is the prediction of LD50 using cell cultures generally valid?

ED50 Calculator

LD50 Calculator