The differences between PBS and HBSS are listed in the table below.
| PBS | HBSS |
| PBS is a buffered solution | HBSS is a balanced form solution |
| Is mainly found in liquid form | Can be found in liquid or powder form |
| Is used in biochemistry and molecular biology experiments specifically | Is used widely in biological research in general |
| Its ingredients are NaCl, KCL, Na2HPO4, and KH2PO4 | Its ingredients are inorganic salts, glucose, phenol red, and sodium bicarbonate |
| Its storage temperature is between 15-30 degrees Celsius | Its storage temperature is between 4-8 degrees Celsius |
| Its applications are washing cells, diluting cells, preparing reagents, and transporting tissue | It is used for mammalian cell culture and transporting media |