What are the differences between phage display and hybridoma?

There are several differences between phage display and hybridomas. The phage display process is fast and it can screen a larger diversity of antibodies. However, it is more expensive, more difficult to do, and the binders may have a lower affinity. Hybridomas can generate large amounts of antibodies with high specificity and high sensitivity at a lower cost. But they do require a longer generation time and often require humanization.