What are the differences between proteasome and protease?

Question

Accepted Answer

Basis of differentiation

Proteasome

Protease

Definition

Proteasome is a protein complexes which degrade unnecessary or damaged proteins through proteolysis

Protease is an enzyme which breaks down peptides and proteins

pH dependency

Proteasome does not depend on pH for its activity

Proteases are highly dependent on pH for its activity

Structure

Is a comparatively larger molecule with a core particle and regulatory cap

Proteases are comparatively smaller with catalytic domain

Molecular weight

Proteasomes are high molecular weight molecules

Proteses have comparatively lower molecular weights

Function

Primary functions of proteasomes include protein unfolding and preliminary cleavage

Primary function is the complete cleavage of protein molecules into individual amino acids

Ubiquitin dependency

Proteasome depends on ubiquitin for its activity

Proteases do not depend on ubiquitin for their activity

Basis of differentiation	Proteasome	Protease
Definition	Proteasome is a protein complexes which degrade unnecessary or damaged proteins through proteolysis	Protease is an enzyme which breaks down peptides and proteins
pH dependency	Proteasome does not depend on pH for its activity	Proteases are highly dependent on pH for its activity
Structure	Is a comparatively larger molecule with a core particle and regulatory cap	Proteases are comparatively smaller with catalytic domain
Molecular weight	Proteasomes are high molecular weight molecules	Proteses have comparatively lower molecular weights
Function	Primary functions of proteasomes include protein unfolding and preliminary cleavage	Primary function is the complete cleavage of protein molecules into individual amino acids
Ubiquitin dependency	Proteasome depends on ubiquitin for its activity	Proteases do not depend on ubiquitin for their activity