AAT Bioquest

What are the functions of CD14?

Posted November 23, 2022


CD14 is a glycosylphosphatidylinositol (GPI)-anchored receptor that may be expressed by cells of both hematopoietic and non-hematopoietic origin as a cell membrane or secreted protein. CD14 plays a key role in protecting the host against infections and in regulating cell metabolism in conditions predisposing to obesity. It acts as a co-receptor for the detection of bacterial lipopolysaccharide. It is essential for the host defense response in the lung against Gram-negative bacteria, such as nontypeable Haemophilus influenza and A. baumannii and E. coli. 

Additional resources

CD14 (cluster of differentiation 14)

TRITC Anti-human CD14 Antibody *61D3*

Purified Anti-human CD14 Antibody *61D3*

Cluster of Differentiation (CD Antibodies)

CD14: Biology and role in the pathogenesis of disease

Gram Staining