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What are the limitations of single-nucleotide polymorphism (SNP) technique?
Posted June 4, 2024

Answer

Limitations of Single Nucleotide Polymorphism (SNP) Technique:

  • The biallelic nature of SNPs reduces their informativity per locus compared to STRs
  • Array platforms that run multiple SNPs simultaneously typically demand larger amounts of DNA than is possible to obtain from a small or degraded sample
  • Currently limited data on X-chromosome SNP usage in forensic analysis (despite studies suggesting potential applicability in population characterization and relationship testing)