What diseases are associated with acetylcholine dysfunction?

Acetylcholine dysfunction is associated with multiple medical conditions. Some of the more common diseases associated with low levels or deficiency of this neurotransmitter include: 

• Alzheimer’s disease: Alzheimer’s disease is a progressive, untreatable neurodegenerative condition that is caused by deficiency of acetylcholine in the brain. It is characterized by severe memory loss and cognitive problems that manifest as confusion, disorientation, poor judgment, and other symptoms that significantly disrupt daily functioning.  
• Myasthenia gravis: Myasthenia gravis is an autoimmune condition that is caused when some of the antibodies in the immune system mistakenly block or damage acetylcholine receptors, preventing the flow of acetylcholine to certain muscles. Muscles that do not receive the neurotransmitter cannot contract and are unable to function normally. This condition is characterized by muscle weakness and fatigue, especially after periods of activity.   
• Parkinson’s disease: Parkinson’s disease is a progressive neurodegenerative condition that is thought to be caused by lower dopamine levels that allow acetylcholine to become more predominant. This excessive increase of acetylcholine triggers undue excitation of muscles, manifesting in symptoms such as involuntary jerky movements, uncontrollable tremors, and difficulties related to cognition and mood. 
• Lambert-Eaton myasthenic syndrome: Caused by a decrease in the release of acetylcholine from nerve cells, this rare condition is characterized by distinct symptoms including diminished tendon reflexes and proximal muscles.