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AAT Bioquest

What happens to a cell when it is internalized?

Posted June 22, 2023


Answer

After internalization, the engulfed vesicle is sorted into a transcytotic vesicle in order to protect itself from endosomal degradation. The transcytotic vesicle is then transported to the opposite side of the cell, where the vesicle membrane fuses with the cell membrane. The components of the vesicle are then secreted. In certain cases, the cell may be able to survive inside the host cell. For example, in entosis the cell may survive within the entotic vacuole for a certain amount of time. Another thing that may happen after internalization is that phagocytosis or cell cannibalism may cause the cell to become degraded. Lastly, the host cell may remove the internalized cell from its cytoplasm through exocytosis. This occurs when the internalized cell is recognized as a harmful substance by the host cell.

Additional resources

Endocytosis

Cell Viability Assays

Apoptosis and Necrosis

Cell Meter™ Apoptotic and Necrotic Multiplexing Detection Kit I *Triple Fluorescence Colors*