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AAT Bioquest

What is reduced Representation Sequencing (RRS)?

Posted April 18, 2024


Answer

Reduced-representation sequencing (RRS) is a method used to produce comprehensive high-throughput sequencing data representing the genetic diversity of a species. This approach simplifies sequencing by focusing on sequencing only a subset of digested genomic fragments. As a result, RRS provides a simplified representation of the genome while capturing a large number of genetic polymorphisms essential for understanding species-wide genetic variations. 

Additional resources

A restriction enzyme reduced representation sequencing approach for low-cost, high-throughput metagenome profiling

Sanger Sequencing

MagaDye™ 535-ddGTP