Karyokinesis is the cell cycle event that is missing in binary fission. Binary fission involves DNA replication, DNA segregation, cell growth, and cell splitting. Since bacteria lack a nucleus, it is not possible for karyokinesis (the division of cell nucleus) to occur. Binary fission is asexual, and
a simplified type of cell division compared to mitosis since prokaryotic cells have a simpler structure compared to eukaryotic cells.