Which metabolic pathway produces the most ATP?

Oxidative phosphorylation is the metabolic pathway that produces the most ATP. It is a part of the cellular respiration process. The energy required to drive oxidative phosphorylation comes from oxidation-reduction reactions. There are a few other processes that also produce ATP but in much smaller quantities. Glycolysis and Krebs Cycle produce 2 ATP molecules per glucose molecule, while oxidative phosphorylation produces 28 ATP molecules per glucose molecule.