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6-ROXtra™ SE
Superior 6-ROX Replacement
Although ROX dyes have strong fluorescence they are notoriously unstable. Some commercial samples only have a few months' shelf life. Compared to 6-ROX labeling compounds our 6-ROXtra™ dyes have greatly enhanced stability while they have essentially identical spectral properties to those of 6-ROX when conjugated to a biological substrate (such as oligonucleotides). In addition, our 6-ROXtra™ dyes are much more water-soluble than 6-ROX dyes that are essentially insoluble in water and aqueous buffers. Our preliminary studies indicated that 6-ROXtra-derived oligos are more easily purified than the corresponding 6-ROX oligos in most cases. When conjugated to proteins, the fluorescence of 6-ROX is severely quenched while 6-ROXtra™ still shows strong fluorescence.
Stability comparison of 6-ROX versus 6-ROXtra™. Blue bar represents starting fluorescence. Red bar represents remaining fluorescence after 4 weeks at 25 °C
Stability comparison of 6-ROX versus 6-ROXtra™. Blue bar represents starting fluorescence. Red bar represents remaining fluorescence after 4 weeks at 25 °C
CatalogSize
Price
Quantity
3975 mg
Price
4011 mg
Price
 
Physical properties

Molecular weight1030.23
SolventDMSO
Spectral properties

Excitation (nm)578
Emission (nm)595
Storage, safety and handling

H-phraseH303, H313, H333
Hazard symbolXN
Intended useResearch Use Only (RUO)
R-phraseR20, R21, R22
StorageFreeze (< -15 °C); Minimize light exposure
UNSPSC12171501
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Page updated on October 10, 2025