Ac-VAD-CHO [Caspase Inhibitor II]

Ac-VAD-CHO

Caspase Inhibitor II

Ac-VAD-CHO, also known as acetyl-valyl-alanyl-aspartyl-CHO, is a potent and cell-permeable inhibitor of caspases. Caspases are a family of cysteine proteases that play essential roles in apoptosis (programmed cell death) and inflammation. This compound is widely used in scientific research to study the mechanisms of apoptosis and to inhibit caspase activity in various experimental models.

Protocol

SDS

COA

Catalog	Size	Price	Quantity
13320	1 mg	Price

References

View all 8 references: Citation Explorer

Identification of active caspases using affinity-based probes.

Authors:

McStay, Gavin P and Green, Douglas R

Journal:

Cold Spring Harbor protocols (2014): 856-60

Induction of apoptosis in human renal cell carcinoma cells by vitamin E succinate in caspase-independent manner.

Authors:

Wu, Xiu-Xian and Kakehi, Yoshiyuki and Jin, Xing-Hua and Inui, Masashi and Sugimoto, Mikio

Journal:

Urology (2009): 193-9

Induction of apoptosis in renal tubular cells by histone deacetylase inhibitors, a family of anticancer agents.

Authors:

Dong, Guie and Wang, Lysa and Wang, Cong-Yi and Yang, Tianxin and Kumar, M Vijay and Dong, Zheng

Journal:

The Journal of pharmacology and experimental therapeutics (2008): 978-84

Metformin induces apoptosis of pancreatic cancer cells.

Authors:

Wang, Luo-Wei and Li, Zhao-Shen and Zou, Duo-Wu and Jin, Zhen-Dong and Gao, Jun and Xu, Guo-Ming

Journal:

World journal of gastroenterology (2008): 7192-8

Apoptosis of gastric cancer cell line MKN45 by photodynamic treatment with photofrin.

Authors:

Takahira, Kenichiro and Sano, Munetaka and Arai, Hajime and Hanai, Hiroyuki

Journal:

Lasers in medical science (2004): 89-94

Physical properties

Molecular weight	329.35
Solvent	DMSO

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C); Minimize light exposure
UNSPSC	12171501
CAS	147837-52-3

Documents

Protocol
Safety Data Sheet
Certificate of Analysis

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Page updated on October 28, 2025