Z-DEVD-FMK

Z-DEVD-FMK is a specific, irreversible Caspase-3 inhibitor, and also shows potent inhibition on caspase-6, caspase-7, caspase-8, and caspase-10.

Protocol

SDS

COA

Catalog	Size	Price	Quantity
13303	1 mg	Price

References

View all 50 references: Citation Explorer

Rescue of Escherichia coli cells from UV-induced death and filamentation by caspase-3 inhibitor.

Authors:

Wadhawan, Surbhi and Gautam, Satyendra

Journal:

International microbiology : the official journal of the Spanish Society for Microbiology (2019): 369-376

AGEs Induce Apoptosis in Rat Osteoblast Cells by Activating the Caspase-3 Signaling Pathway Under a High-Glucose Environment In Vitro.

Authors:

Liu, Jiaqiang and Mao, Jing and Jiang, Yi and Xia, Lunguo and Mao, Lixia and Wu, Yong and Ma, Pan and Fang, Bing

Journal:

Applied biochemistry and biotechnology (2016): 1015-27

Cleavage of the calpain inhibitor, calpastatin, during postmortem ageing of beef skeletal muscle.

Authors:

Huang, Feng and Huang, Ming and Zhang, Hong and Guo, Bing and Zhang, Dequan and Zhou, Guanghong

Journal:

Food chemistry (2014): 1-6

Increased activity of cell surface peptidases in HeLa cells undergoing UV-induced apoptosis is not mediated by caspase 3.

Authors:

Piva, Terrence J and Davern, Catherine M and Hall, Paula M and Winterford, Clay M and Ellem, Kay A O

Journal:

International journal of molecular sciences (2012): 2650-75

Lysosomal membrane permeabilization is an early event in Sigma-2 receptor ligand mediated cell death in pancreatic cancer.

Authors:

Hornick, John R and Vangveravong, Suwanna and Spitzer, Dirk and Abate, Carmen and Berardi, Francesco and Goedegebuure, Peter and Mach, Robert H and Hawkins, William G

Journal:

Journal of experimental & clinical cancer research : CR (2012): 41

Physical properties

Molecular weight	668.67
Solvent	DMSO

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C); Minimize light exposure
UNSPSC	12171501

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Page updated on October 8, 2025