AAT Bioquest


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ShippingStandard overnight for United States, inquire for international
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Physical properties
Molecular weight668.67
Storage, safety and handling
H-phraseH303, H313, H333
Hazard symbolXN
Intended useResearch Use Only (RUO)
R-phraseR20, R21, R22
StorageFreeze (< -15 °C); Minimize light exposure


See also: Caspases
Molecular weight
Z-DEVD-FMK is a specific, irreversible Caspase-3 inhibitor, and also shows potent inhibition on caspase-6, caspase-7, caspase-8, and caspase-10.


Common stock solution preparation

Table 1. Volume of DMSO needed to reconstitute specific mass of Z-DEVD-FMK to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.

0.1 mg0.5 mg1 mg5 mg10 mg
1 mM149.551 µL747.753 µL1.496 mL7.478 mL14.955 mL
5 mM29.91 µL149.551 µL299.101 µL1.496 mL2.991 mL
10 mM14.955 µL74.775 µL149.551 µL747.753 µL1.496 mL

Molarity calculator

Enter any two values (mass, volume, concentration) to calculate the third.

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View all 50 references: Citation Explorer
Rescue of Escherichia coli cells from UV-induced death and filamentation by caspase-3 inhibitor.
Authors: Wadhawan, Surbhi and Gautam, Satyendra
Journal: International microbiology : the official journal of the Spanish Society for Microbiology (2019): 369-376
AGEs Induce Apoptosis in Rat Osteoblast Cells by Activating the Caspase-3 Signaling Pathway Under a High-Glucose Environment In Vitro.
Authors: Liu, Jiaqiang and Mao, Jing and Jiang, Yi and Xia, Lunguo and Mao, Lixia and Wu, Yong and Ma, Pan and Fang, Bing
Journal: Applied biochemistry and biotechnology (2016): 1015-27
Cleavage of the calpain inhibitor, calpastatin, during postmortem ageing of beef skeletal muscle.
Authors: Huang, Feng and Huang, Ming and Zhang, Hong and Guo, Bing and Zhang, Dequan and Zhou, Guanghong
Journal: Food chemistry (2014): 1-6
Increased activity of cell surface peptidases in HeLa cells undergoing UV-induced apoptosis is not mediated by caspase 3.
Authors: Piva, Terrence J and Davern, Catherine M and Hall, Paula M and Winterford, Clay M and Ellem, Kay A O
Journal: International journal of molecular sciences (2012): 2650-75
Lysosomal membrane permeabilization is an early event in Sigma-2 receptor ligand mediated cell death in pancreatic cancer.
Authors: Hornick, John R and Vangveravong, Suwanna and Spitzer, Dirk and Abate, Carmen and Berardi, Francesco and Goedegebuure, Peter and Mach, Robert H and Hawkins, William G
Journal: Journal of experimental & clinical cancer research : CR (2012): 41
Disassembly of the JIP1/JNK molecular scaffold by caspase-3-mediated cleavage of JIP1 during apoptosis.
Authors: Vaishnav, Mahesh and MacFarlane, Marion and Dickens, Martin
Journal: Experimental cell research (2011): 1028-39
Caspase 3 blocking avoids the expression of autoantigens triggered by apoptosis in neonatal Balb/c mice skin.
Authors: Ramírez-Sandoval, R and Vazquez-del-Mercado, M and Daneri-Navarro, A and Bollain-y-Goytia, J J and Avalos-Diaz, E and Herrera-Esparza, R
Journal: Reumatismo (2011): 29-37
Role of VPO1, a newly identified heme-containing peroxidase, in ox-LDL induced endothelial cell apoptosis.
Authors: Bai, Yong-Ping and Hu, Chang-Ping and Yuan, Qiong and Peng, Jun and Shi, Rui-Zheng and Yang, Tian-Lun and Cao, Ze-Hong and Li, Yuan-Jian and Cheng, Guangjie and Zhang, Guo-Gang
Journal: Free radical biology & medicine (2011): 1492-500
Proteasome activity profiling: a simple, robust and versatile method revealing subunit-selective inhibitors and cytoplasmic, defense-induced proteasome activities.
Authors: Gu, Christian and Kolodziejek, Izabella and Misas-Villamil, Johana and Shindo, Takayuki and Colby, Tom and Verdoes, Martijn and Richau, Kerstin H and Schmidt, Jürgen and Overkleeft, Hermen S and van der Hoorn, Renier A L
Journal: The Plant journal : for cell and molecular biology (2010): 160-70
Evidence for caspase effects on release of cytochrome c and AIF in a model of ischemia in cortical neurons.
Authors: Singh, Maneesh H and Brooke, Sheila M and Zemlyak, Ilona and Sapolsky, Robert M
Journal: Neuroscience letters (2010): 179-83