AAT Bioquest

How do ionic detergents affect protein molecules?

Posted July 28, 2021


Ionic detergents are capable of denaturing protein molecules irreversibly by breaking the intra- and intermolecular interactions. This alters the protein’s charge and structure and destroys their inherent biological activity.  

Additional resources

Quantification of Membrane Protein-Detergent Complex Interactions

Plasma Membrane

DiOC3(3) iodide [3,3-Dipropyloxacarbocyanine iodide]