The Golgi is located in the cytoplasm near the nucleus of the cell and adjacent to the rough endoplasmic reticulum (rough ER). The rough ER is another organelle commonly found in cells that is responsible for synthesizing proteins and lipid molecules. Transport vesicles that detach from the rough ER, which contain newly synthesized materials, are transported to the Golgi, where they fuse with cis region of the Golgi membrane and unload their contents into the lumen. Once inside, the Golgi is responsible for processing and packaging these proteins into vesicles for transport to targeted destinations within the cells or to the extracellular matrix