Yes, mRNAs found in prokaryotes differ from those of eukaryotes in a number of ways. Here’s a look at the differences between prokaryotic mRNA and eukaryotic mRNA: 

Prokaryotic mRNA:

• Is synthesized in the cytoplasm by the transcription of operons
• Is polycistronic (codes for more than one protein)
• Transcription is coupled with translation 
• Does not contain both 5′ cap and 3′ tail
• Has a very short lifespan and undergoes very little modifications after transcription

Eukaryotic mRNA:

• Is synthesized in the nucleus by the transcription of single genes
• Is monocistronic (codes for a single protein)
• Translation occurs only after transcription is complete
• Contains both 5′ cap and 3′ tail
• Has a relatively long and stable lifespan and undergoes major modifications after transcription