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AAT Bioquest

How do the two types of weak bonds work?

Posted February 14, 2024


Answer

The two types of weak bonds in biology are van der Waals interactions and hydrogen bonds. 

  • Hydrogen bonds play a crucial role in water's essential properties for sustaining life. Additionally, they contribute to stabilizing the structures of proteins and DNA, which are fundamental components of cells. Hydrogen bonds also help determine and stabilize the three-dimensional structure of proteins. These bonds form between the two strands of DNA, involving complementary base pairing. While each hydrogen bond is relatively weak on its own, the collective strength of these bonds is significant. This complementary base pairing serves as a template during DNA replication.
  • Van der Waals interactions are weak electrostatic attractions which pull neutral molecules towards each other. These interactions take place between polar covalently attached atoms in various types of molecules. The weak attractions arise from temporary partial charges that are produced when electrons move around a nucleus. This is because in liquids or gasses, particles are in constant motion, vibrating and colliding with one another. When a molecule with such a charge imbalance is in close proximity to another molecule, it can induce a similar mechanism in the second molecule. As a result, the temporary positive and negative charges of the two molecules attract each other. These interactions between molecules play a crucial role in biological systems and are dependent on physical proximity. 
Additional resources

Weaker Bonds in Biology

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