What are the advantages of enzymatic fragmentation?

Enzyme-based DNA fragmentation has several advantages. One advantage is that it eliminates the need for investment in specialized equipment, making it cost-effective. Additionally, enzyme-based fragmentation minimizes sample loss during processing, ensuring maximal utilization of precious biological samples. Furthermore, it facilitates rapid processing of multiple samples simultaneously, enhancing the workflow efficiency. Enzymatic fragmentation often also leads to higher library yields compared to mechanical shearing workflows. In addition, this type of fragmentation is notably gentler on the sample, resulting in less damage even when processing at various scales.