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AAT Bioquest

What are the advantages of third generation NGS?

Posted March 11, 2024


Answer

Third generation sequencing technologies offer significant advantages over other methods by producing longer reads (1500-100,000 base pairs). Third generation sequencing technologies offer additional benefits, such as faster sequencing and portability. Compared to second generation sequencing, they require minimal sample preparation, allowing for the design of smaller, more portable equipment. A third advantage is third generation sequencing could potentially detect epigenetic markers directly, as they produce a unique signal different from the four nucleotide bases, simplifying the detection process.

 

Additional resources

Third-Generation Sequencing: The Spearhead towards the Radical Transformation of Modern Genomics

Next Generation Sequencing (NGS)

5-Propargylamino-3'-azidomethyl-dCTP